Brain State Laboratory

Publications

Peer-reviewed articles, preprints and book chapters, newest first. Each entry links to its published record where one exists.

Peer-reviewed articles

46

2026

  1. Makhoul GS, Johnson GW, Reda A, Hidalgo Monroy Lerma B, Fan JM, Worrell GA, Englot DJ. Pathway to Adaptive Neuromodulation: Modeling Epileptogenic Brain States Using SEEG. Epilepsy Curr. 2026 Feb 19;15357597261422447. doi: 10.1177/15357597261422447. PMID: 41726571. PMCID: PMC12920160.

  2. Hidalgo Monroy Lerma B, Makhoul GS, Reda A, Cavender AC, Doss DJ, Withers CP, Wang K, Johnson GW, Funk C, Crudele AN, Englot DJ. Inpatient continuous thalamic stereo-electroencephalography stimulation in the evaluation of focal epilepsy: illustrative case. J Neurosurg Case Lessons. 2026 Apr 6;11(14). doi: 10.3171/CASE25947. PMID: 41941831. PMCID: PMC13051662.

  3. Qian H, Johnson GW, Hughes NC, Chao A, Long IC, Paulo DL, Zhao Z, Subramanian D, Taylor WD, Dhima K, Bick SK. Movement Disorder Patients with Depression Have Altered Corticostriatal Alpha-Beta Power Response to Reward and Loss. eNeuro. 2026 Jul;13(7). doi: 10.1523/ENEURO.0008-26.2026. Epub 2026 Jul 13. PMID: 42386530. PMCID: PMC13364504.

  4. Cavender AC, Doss DJ, Makhoul GS, Lerma BHM, Reda A, Withers CP, Liao E, Wang K, González HFJ, Goodale SE, Johnson GW, Cutting LE, Bick SK, Chang C, Morgan VL, Englot DJ. Nucleus basalis functional connectivity aberrations in temporal lobe epilepsy and improvements after successful epilepsy surgery. Epilepsia. 2026 Aug 19. doi: 10.1002/epi.70451. PMID: 42615230.

2025

  1. Doss DJ, Gummadavelli A, Johnson GW, Makhoul GS, Shless JS, Bibro CE, Jacobs ML, Kang H, Haas KF, Bick SK, Terry DP, Dawant BM, Chang C, Morgan VL, Englot DJ. Impact of disease duration and surgical intervention on arousal networks in temporal lobe epilepsy. J Neurosurg. 2025 Jun 1;142(6):1525-1534. doi: 10.3171/2024.8.JNS241079. Epub 2025 Jan 24. PMID: 39854724. PMCID: PMC12129691.

  2. Hughes NC, Qian H, Doss DJ, Makhoul GS, Zargari M, Zhao Z, Singh B, Wang Z, Fulton JN, Johnson GW, Li R, Dawant BM, Englot DJ, Constantinidis C, Williams Roberson S, Bick SK. Reward circuit local field potential modulations precede risk taking. Brain. 2025 Nov 4;148(11):3958-3972. doi: 10.1093/brain/awaf107. PMID: 40101145. PMCID: PMC12588683.

  3. Feng E, Jayasuriya NM, Nathani KR, Katsos K, Machlab LA, Johnson GW, Freedman BA, Bydon M. Artificial intelligence image analysis for Hounsfield units in preoperative thoracolumbar CT scans: an automated screening for osteoporosis in patients undergoing spine surgery. J Neurosurg Spine. 2025 Jul 1;43(1):1-8. doi: 10.3171/2025.1.SPINE24900. Epub 2025 Apr 18. PMID: 40250051.

  4. Sundrani S, Johnson GW, Doss DJ, Makhoul GS, Hidalgo Monroy Lerma B, Reda A, Cavender AC, Liao E, Rogers BP, Williams Roberson S, Bick SK, Morgan VL, Englot DJ. Deep learning on brief interictal intracranial recordings can accurately characterize seizure onset zones. Epilepsia. 2025 Sep;66(9):3180-3192. doi: 10.1111/epi.18478. Epub 2025 May 27. PMID: 40423629. PMCID: PMC12354104.

  5. Makhoul GS, Doss DJ, Johnson GW, Withers CP, Cavender AC, Hidalgo Monroy Lerma B, Reda A, Bibro CE, Liao E, Kang H, Dawant BM, Reddy SB, Crudele AN, Constantinidis C, Williams Roberson S, Bick SK, Morgan VL, Englot DJ. Collapse of interictal suppressive networks permits seizure spread. Brain. 2025 Dec 4;148(12):4275-4287. doi: 10.1093/brain/awaf215. PMID: 40473247. PMCID: PMC13370126.

  6. Sundrani S, Doss DJ, Johnson GW, Jain H, Zakieh O, Wegner AM, Lugo-Pico JG, Abtahi AM, Stephens BF, Zuckerman SL. Does alignment alone predict mechanical complications after adult spinal deformity surgery? A machine learning comparison of alignment, bone quality, and soft tissue. Neurosurg Focus. 2025 Jul 1;59(1):E15. doi: 10.3171/2025.4.FOCUS25245. PMID: 40591962.

  7. Reda A, Doss DJ, Makhoul GS, Monroy Lerma BH, Johnson G, Sainburg LE, Cavender AC, Sundrani S, Liao E, Roche A, Long I, Kang H, Dawant B, Chang C, Bick SK, Nobis WP, Morgan V, Englot DJ. Altered Interictal Bed Nucleus of Stria Terminalis Connectivity in Patients With Temporal Lobe Epilepsy. Neurology. 2025 Dec 9;105(11):e214385. doi: 10.1212/WNL.0000000000214385. Epub 2025 Nov 13. PMID: 41232063. PMCID: PMC13439677.

  8. Lampert F, Baker MR, Jensen MA, Ayyoubi AH, Bentler C, Bowersock JL, Esteller R, Herron JA, Johnson GW, Kipke DR, Kovach CK, Kremen V, Mivalt F, Neimat JS, Netoff TI, Opri E, Rockhill A, Rosenow JM, Sellers KK, Staff NP, Swamy CP, Viswanathan A, Schalk G, Denison T, Hermes D, Ince NF, Brunner P, Worrell GA, Miller KJ. Adaptive neuromodulation dialogues: navigating current challenges and emerging innovations in neuromodulation system development. J Neural Eng. 2025 Dec 19;22(6). doi: 10.1088/1741-2552/ae2359. PMID: 41285049. PMCID: PMC12715846.

2024

  1. Johnson GW, Chanbour H, Doss DJ, Makhoul GS, Abtahi AM, Stephens BF, Zuckerman SL. Pseudarthrosis following adult spinal deformity surgery may be predicted with preoperative MRI adipose tissue features: an artificial intelligence study on raw 3D imaging. Artificial Intelligence Surgery. 2024;4(4):401-10. doi: 10.20517/ais.2024.40.

    First author

  2. Singh B, Wang Z, Madiah LM, Gatti SE, Fulton JN, Johnson GW, Li R, Dawant BM, Englot DJ, Bick SK, Roberson SW, Constantinidis C. Brain-wide human oscillatory local field potential activity during visual working memory. iScience. 2024 Mar 15;27(3):109130. doi: 10.1016/j.isci.2024.109130. Epub 2024 Feb 5. PMID: 38380249. PMCID: PMC10877957.

  3. Doss DJ, Johnson GW, Makhoul GS, Rashingkar RV, Shless JS, Bibro CE, Paulo DL, Gummadavelli A, Ball TJ, Reddy SB, Naftel RP, Haas KF, Dawant BM, Constantinidis C, Williams Roberson S, Bick SK, Morgan VL, Englot DJ. Network signatures define consciousness state during focal seizures. Epilepsia. 2024. doi: 10.1111/epi.18074.

  4. Akbarian B, Sainburg LE, Janson A, Johnson GW, Doss DJ, Rogers BP, Englot DJ, Morgan VL. Association Between Postsurgical Functional Connectivity and Seizure Outcome in Patients With Temporal Lobe Epilepsy. Neurology. 2024 Oct 8;103(7):e209816. doi: 10.1212/WNL.0000000000209816. Epub 2024 Sep 3. PMID: 39226517; PMCID: PMC11373675.

  5. Doss DJ, Shless JS, Bick SK, Makhoul GS, Negi AS, Bibro CE, Rashingkar R, Gummadavelli A, Chang C, Gallagher MJ, Naftel RP, Reddy SB, Williams-Roberson S, Morgan VL, Johnson GW, Englot DJ. The interictal suppression hypothesis is the dominant differentiator of seizure onset zones in focal epilepsy. Brain. 2024 Jun 14:awae189. doi: 10.1093/brain/awae189. Epub ahead of print. PMID: 38874456.

  6. Younus I, Chanbour H, Chen JW, Johnson GW, Metcalf T, Lyons AT, Jonzzon S, Liles C, Roth SG, Abtahi AM, Stephens BF, Zuckerman SL. Combined Anterior-Posterior vs. Posterior-Only Approach in Adult Spinal Deformity Surgery: Which Strategy Is Superior? J Clin Med. 2024 Jan 24;13(3):682. doi: 10.3390/jcm13030682. PMID: 38337376; PMCID: PMC10856410.

  7. Cai LY, Lee HH, Johnson GW, Newlin NR, Ramadass K, Kim ME, Archer DB, Hohman TJ, Jefferson AL, Begnoche JP, Boyd BD, Taylor WD, Morgan VL, Englot DJ, Nath V, Chotai S, Barquero L, D'Archangel M, Cutting LE, Dawant BM, Rheault F, Moyer DC, Schilling KG, Gore JC, Landman BA. (2024, July). Tractography from T1-weighted MRI: empirically exploring the clinical viability of streamline propagation without diffusion MRI. Imaging Neuroscience.

  8. Jonzzon S, Chanbour H, Johnson GW, Chen JW, Metcalf T, Lyons AT, Younus I, Liles C, Abtahi AM, Stephens BF, et al. Who Can Be Discharged Home after Adult Spinal Deformity Surgery? Journal of Clinical Medicine. 2024; 13(5):1340. https://doi.org/10.3390/jcm13051340

  9. Janson A, Sainburg L, Akbarian B, Johnson GW, Rogers BP, Chang C, Englot DJ, Morgan VL. Indirect structural changes and reduced controllability after temporal lobe epilepsy resection. Epilepsia. 2024 Jan 19. doi: 10.1111/epi.17889. Epub ahead of print. PMID: 38240699.

2023

  1. Chanbour H, Bendfeldt GA, Johnson GW, Peterson K, Ahluwalia R, Younus I, Longo M, Abtahi AM, Stephens BF, Zuckerman SL. Longer Screws Decrease the Risk of Radiographic Pseudarthrosis Following Elective Anterior Cervical Discectomy and Fusion. Global Spine J. 2023 Nov 11:21925682231214361. doi: 10.1177/21925682231214361. Epub ahead of print. PMID: 37950628.

  2. Johnson GW, Chanbour H, Ali MA, Chen J, Metcalf T, Doss DJ, Younus I, Jonzzon S, Roth SG, Abtahi AM, Stephens BF, Zuckerman SL. Artificial Intelligence to Preoperatively Predict Proximal Junction Kyphosis Following Adult Spinal Deformity Surgery: Soft Tissue Imaging May be Necessary for Accurate Models. Spine. 2023. ():10.1097/BRS.0000000000004816, August 30, 2023. | DOI: 10.1097/BRS.0000000000004816. PMID: 37644737

    First author

  3. Johnson GW, Doss DJ, Jiang JW, Paulo DL, Cai LY, Shless JS, Negi AS, Gummadavelli A, Kang H, Reddy SB, Naftel RP, Bick SK, Williams Roberson S, Dawant BM, Wallace MT, Englot DJ. The interictal suppression hypothesis in focal epilepsy: network-level supporting evidence. Brain. 2023 Feb 1: doi: 10.1093/brain/awad016. PMID: 36722219.

    First author

  4. *Paulo DL, *Johnson GW, Doss DJ, Allen JH, González HFJ, Shults R, Li R, Ball TJ, Bick SK, Hassell TJ, D'Haese PF, Konrad PE, Dawant BM, Narasimhan S, Englot DJ. Intraoperative physiology augments atlas-based data in awake deep brain stimulation. J Neurol Neurosurg Psychiatry. 2023 Sep 7:jnnp-2023-331248. doi: 10.1136/jnnp-2023-331248. PMID: 37679029 *Equal Contribution

    Co-first author

  5. Doss DJ, Johnson GW, Narasimhan S, Jiang JW, Gonzalez HFJ, Paulo DL, Lucas A, Davis KA, Chang CE, Morgan VL, Constantinidis C, Dawant BM, Englot DJ. Deep learning segmentation of the nucleus basalis of Meynert on 3T MRI. AJNR Am J Neuroradiol. 2023 Aug 10. doi: 10.3174/ajnr.A7950. Epub ahead of print. PMID: 37562826.

  6. Cai LY, Lee HH, Newlin NR, Kerley CI, Kanakaraj P, Yang Q, Johnson GW, Moyer D, Schilling KG, Rheault F, Landman BA. Convolutional-recurrent neural networks approximate diffusion tractography from T1-weighted MRI and associated anatomical context. In Proceedings of Machine Learning Research. 2023.

  7. Paulo DL, Qian H, Subramanian D, Johnson GW, et al., Corticostriatal beta oscillation changes associated with cognitive function in Parkinson’s disease. Brain. 2023;doi:10.1093/brain/awad206

  8. Jiang JW, Narasimhan S, Johnson GW, González HFJ, Doss DJ, Shless JS, Paulo DL, Terry DP, Chang C, Morgan VL, Englot DJ. Abnormal functional connectivity of the posterior hypothalamus and other arousal regions in surgical temporal lobe epilepsy. J Neurosurg. 2023 Feb 17:1-11. doi: 10.3171/2023.1.JNS221452. PMID: 36807210.

  9. Sainburg LE, Janson AP, Johnson GW, Jiang JW, Rogers BP, Chang C, Englot DJ, Morgan VL. Structural disconnection relates to functional changes after temporal lobe epilepsy surgery. Brain. 2023 Apr 5:awad117. doi: 10.1093/brain/awad117. PMID: 37018067.

  10. Nanda A, Johnson GW, Mu Y, Ahrens MB, Chang C, Englot DJ, Breakspear M, Rubinov M. Time-resolved correlation of distributed brain activity tracks E-I balance and accounts for diverse scale-free phenomena. Cell Rep. 2023 Mar 24;42(4):112254. doi: 10.1016/j.celrep.2023.112254. Epub ahead of print. PMID: 36966391.

2022

  1. Johnson GW, Cai LY, Doss DJ, Jiang JW, Negi AS, Narasimhan S, Paulo DL, González HFJ, Williams Roberson S, Bick SK, Chang CE, Morgan VL, Wallace MT, Englot DJ. Localizing seizure onset zones in surgical epilepsy with neurostimulation deep learning. J Neurosurg. 2022 Sep 23:1-6. doi: 10.3171/2022.8.JNS221321. PMID: 36152321.

    First author

  2. González HFJ, Narasimhan S, Goodale SE, Johnson GW, Doss DJ, Paulo DL, Morgan VL, Chang C, Englot DJ. Arousal and salience network connectivity alterations in surgical temporal lobe epilepsy. J Neurosurg. 2022 Jul 8;138(3):810-820. doi: 10.3171/2022.5.JNS22837. PMID: 35901709.

  3. *Sinha N, *Johnson GW, Davis KA, Englot DJ. Integrating Network Neuroscience Into Epilepsy Care: Progress, Barriers, and Next Steps. Epilepsy Curr. 2022 May 13;22(5):272-278. doi: 10.1177/15357597221101271. PMID: 36285209; PMCID: PMC9549227. *Equal contribution.

    Co-first author

  4. Morgan VL, Sainburg LE, Johnson GW, Janson A, Levine KK, Rogers BP, Chang C, Englot DJ. Presurgical temporal lobe epilepsy connectome fingerprint for seizure outcome prediction. Brain Commun. 2022 May 17;4(3):fcac128. doi: 10.1093/braincomms/fcac128. PMID: 35774185; PMCID: PMC9237708.

  5. Sainburg LE, Little AA, Johnson GW, Janson AP, Levine KK, González HFJ, Rogers BP, Chang C, Englot DJ, Morgan VL. Characterization of resting functional MRI activity alterations across epileptic foci and networks. Cereb Cortex. 2022 Dec 8;32(24):5555-5568. doi: 10.1093/cercor/bhac035. PMID: 35149867; PMCID: PMC9753043.

  6. Paulo DL, Wills KE, Johnson GW, Gonzalez HFJ, Rolston JD, Naftel RP, Reddy SB, Morgan VL, Kang H, Williams Roberson S, Narasimhan S, Englot DJ. SEEG Functional Connectivity Measures to Identify Epileptogenic Zones: Stability, Medication Influence, and Recording Condition. Neurology. 2022 May 17;98(20):e2060-e2072. doi: 10.1212/WNL.0000000000200386. Epub 2022 Mar 25. PMID: 35338075; PMCID: PMC9162047.

  7. Johnson GW, Cai LY, Narasimhan S, González HFJ, Wills KE, Morgan VL, Englot DJ. Temporal lobe epilepsy lateralisation and surgical outcome prediction using diffusion imaging. J Neurol Neurosurg Psychiatry. 2022 Jun;93(6):599-608. doi: 10.1136/jnnp-2021-328185. Epub 2022 Mar 28. PMID: 35347079; PMCID: PMC9149039.

    First author

  8. Narasimhan S, González HFJ, Johnson GW, Wills KE, Paulo DL, Morgan VL, Englot DJ. Functional connectivity between mesial temporal and default mode structures may help lateralize surgical temporal lobe epilepsy. J Neurosurg. 2022 Apr 1;137(6):1571-1581. doi: 10.3171/2022.1.JNS212031. PMID: 35364587; PMCID: PMC9525455.

  9. Johnson GW, Doss DJ, Englot DJ. Network dysfunction in pre and postsurgical epilepsy: connectomics as a tool and not a destination. Curr Opin Neurol. 2022 Apr 1;35(2):196-201. doi: 10.1097/WCO.0000000000001008. PMID: 34799514; PMCID: PMC8891078.

    First author

2021

  1. Morgan VL, Johnson GW, Cai LY, Landman BA, Schilling KG, Englot DJ, Rogers BP, Chang C. MRI network progression in mesial temporal lobe epilepsy related to healthy brain architecture. Netw Neurosci. 2021 Apr 27;5(2):434-450. doi: 10.1162/netn_a_00184. PMID: 34189372; PMCID: PMC8233120.

  2. Cai LY, Yang Q, Hansen CB, Nath V, Ramadass K, Johnson GW, Conrad BN, Boyd BD, Begnoche JP, Beason-Held LL, Shafer AT, Resnick SM, Taylor WD, Price GR, Morgan VL, Rogers BP, Schilling KG, Landman BA. PreQual: An automated pipeline for integrated preprocessing and quality assurance of diffusion weighted MRI images. Magn Reson Med. 2021 Jul;86(1):456-470. doi: 10.1002/mrm.28678. Epub 2021 Feb 3. PMID: 33533094; PMCID: PMC8387107.

  3. Wills KE, González HFJ, Johnson GW, Haas KF, Morgan VL, Narasimhan S, Englot DJ. People with mesial temporal lobe epilepsy have altered thalamo-occipital brain networks. Epilepsy Behav. 2021 Feb;115:107645. doi: 10.1016/j.yebeh.2020.107645. Epub 2020 Dec 15. PMID: 33334720; PMCID: PMC7882020.

  4. González HFJ, Narasimhan S, Johnson GW, Wills KE, Haas KF, Konrad PE, Chang C, Morgan VL, Rubinov M, Englot DJ. Role of the Nucleus Basalis as a Key Network Node in Temporal Lobe Epilepsy. Neurology. 2021 Mar 2;96(9):e1334-e1346. doi: 10.1212/WNL.0000000000011523. Epub 2021 Jan 13. PMID: 33441453; PMCID: PMC8055321.

2020

  1. Narasimhan S, Kundassery KB, Gupta K, Johnson GW, Wills KE, Goodale SE, Haas K, Rolston JD, Naftel RP, Morgan VL, Dawant BM, González HFJ, Englot DJ. Seizure-onset regions demonstrate high inward directed connectivity during resting-state: An SEEG study in focal epilepsy. Epilepsia. 2020 Nov;61(11):2534-2544. doi: 10.1111/epi.16686. Epub 2020 Sep 18. PMID: 32944945; PMCID: PMC7899016.

  2. Goodale SE, González HFJ, Johnson GW, Gupta K, Rodriguez WJ, Shults R, Rogers BP, Rolston JD, Dawant BM, Morgan VL, Englot DJ. Resting-State SEEG May Help Localize Epileptogenic Brain Regions. Neurosurgery. 2020 Jun 1;86(6):792-801. doi: 10.1093/neuros/nyz351. PMID: 31814011; PMCID: PMC7225010.

Preprints

2

2025

  1. Johnson GW, Makhoul GS, Doss DJ, Monroy Lerma BH, Cai LY, et al. (36 authors; Worrell GA, Miller KJ, Englot DJ last three). Generalized brain-state modeling with KenazLBM. bioRxiv. Posted 2025-08-12 (v3 2025-09-12). doi: 10.1101/2025.08.10.669538. First and corresponding author.

    First author

2024

  1. Johnson GW, Doss DJ, Makhoul GS, Cai LY, Bibro CE, Paulo DL, Reddy SB, Naftel RP, Haas KF, Wallace MT, Dawant BM, Crudele AN, Morgan VL, Constantinidis C, Roberson SW, Bick SK, Englot DJ. Brain-state modeling using electroencephalography: Application to adaptive closed-loop neuromodulation for epilepsy. bioRxiv. 2024-06-01. doi: 10.1101/2024.06.01.596884. First and corresponding author. Preprint: Crossref type posted-content; no journal version indexed as of 2026-09-11.

    First author

Book chapters

1

n.d.

  1. Doss DJ, Johnson GW, Englot DJ. Chapter 5: Imaging and SEEG Functional Networks to Guide Epilepsy Surgery, NEC 35.1 (Yang/Richardson) Epilepsy Surgery: Paradigm Shifts