Brain State Laboratory

Publications

Peer-reviewed articles, preprints and book chapters, newest first. Each entry links to its published record where one exists.

Peer-reviewed articles

46

2026

  1. Pathway to Adaptive Neuromodulation: Modeling Epileptogenic Brain States Using SEEG

    Makhoul GS, Johnson GW, Reda A, Hidalgo Monroy Lerma B, Fan JM, Worrell GA, Englot DJ

    Epilepsy Currdoi:10.1177/15357597261422447

  2. Inpatient continuous thalamic stereo-electroencephalography stimulation in the evaluation of focal epilepsy: illustrative case

    Hidalgo Monroy Lerma B, Makhoul GS, Reda A, Cavender AC, Doss DJ, Withers CP, Wang K, Johnson GW, Funk C, Crudele AN, Englot DJ

    J Neurosurg Case Lessonsdoi:10.3171/CASE25947

  3. Movement Disorder Patients with Depression Have Altered Corticostriatal Alpha-Beta Power Response to Reward and Loss

    Qian H, Johnson GW, Hughes NC, Chao A, Long IC, Paulo DL, Zhao Z, Subramanian D, Taylor WD, Dhima K, Bick SK

    eNeurodoi:10.1523/ENEURO.0008-26.2026

  4. Nucleus basalis functional connectivity aberrations in temporal lobe epilepsy and improvements after successful epilepsy surgery

    Cavender AC, Doss DJ, Makhoul GS, Lerma BHM, Reda A, Withers CP, Liao E, Wang K, González HFJ, Goodale SE, Johnson GW, Cutting LE, Bick SK, Chang C, Morgan VL, Englot DJ

    Epilepsiadoi:10.1002/epi.70451

2025

  1. Impact of disease duration and surgical intervention on arousal networks in temporal lobe epilepsy

    Doss DJ, Gummadavelli A, Johnson GW, Makhoul GS, Shless JS, Bibro CE, Jacobs ML, Kang H, Haas KF, Bick SK, Terry DP, Dawant BM, Chang C, Morgan VL, Englot DJ

    J Neurosurgdoi:10.3171/2024.8.JNS241079

  2. Reward circuit local field potential modulations precede risk taking

    Hughes NC, Qian H, Doss DJ, Makhoul GS, Zargari M, Zhao Z, Singh B, Wang Z, Fulton JN, Johnson GW, Li R, Dawant BM, Englot DJ, Constantinidis C, Williams Roberson S, Bick SK

    Braindoi:10.1093/brain/awaf107

  3. Artificial intelligence image analysis for Hounsfield units in preoperative thoracolumbar CT scans: an automated screening for osteoporosis in patients undergoing spine surgery

    Feng E, Jayasuriya NM, Nathani KR, Katsos K, Machlab LA, Johnson GW, Freedman BA, Bydon M

    J Neurosurg Spinedoi:10.3171/2025.1.SPINE24900

  4. Deep learning on brief interictal intracranial recordings can accurately characterize seizure onset zones

    Sundrani S, Johnson GW, Doss DJ, Makhoul GS, Hidalgo Monroy Lerma B, Reda A, Cavender AC, Liao E, Rogers BP, Williams Roberson S, Bick SK, Morgan VL, Englot DJ

    Epilepsiadoi:10.1111/epi.18478

  5. Collapse of interictal suppressive networks permits seizure spread

    Makhoul GS, Doss DJ, Johnson GW, Withers CP, Cavender AC, Hidalgo Monroy Lerma B, Reda A, Bibro CE, Liao E, Kang H, Dawant BM, Reddy SB, Crudele AN, Constantinidis C, Williams Roberson S, Bick SK, Morgan VL, Englot DJ

    Braindoi:10.1093/brain/awaf215

  6. Does alignment alone predict mechanical complications after adult spinal deformity surgery? A machine learning comparison of alignment, bone quality, and soft tissue

    Sundrani S, Doss DJ, Johnson GW, Jain H, Zakieh O, Wegner AM, Lugo-Pico JG, Abtahi AM, Stephens BF, Zuckerman SL

    Neurosurg Focusdoi:10.3171/2025.4.FOCUS25245

  7. Altered Interictal Bed Nucleus of Stria Terminalis Connectivity in Patients With Temporal Lobe Epilepsy

    Reda A, Doss DJ, Makhoul GS, Monroy Lerma BH, Johnson G, Sainburg LE, Cavender AC, Sundrani S, Liao E, Roche A, Long I, Kang H, Dawant B, Chang C, Bick SK, Nobis WP, Morgan V, Englot DJ

    Neurologydoi:10.1212/WNL.0000000000214385

  8. Adaptive neuromodulation dialogues: navigating current challenges and emerging innovations in neuromodulation system development

    Lampert F, Baker MR, Jensen MA, Ayyoubi AH, Bentler C, Bowersock JL, Esteller R, Herron JA, Johnson GW, Kipke DR, Kovach CK, Kremen V, Mivalt F, Neimat JS, Netoff TI, Opri E, Rockhill A, Rosenow JM, Sellers KK, Staff NP, Swamy CP, Viswanathan A, Schalk G, Denison T, Hermes D, Ince NF, Brunner P, Worrell GA, Miller KJ

    J Neural Engdoi:10.1088/1741-2552/ae2359

2024

  1. Pseudarthrosis following adult spinal deformity surgery may be predicted with preoperative MRI adipose tissue features: an artificial intelligence study on raw 3D imaging

    Johnson GW, Chanbour H, Doss DJ, Makhoul GS, Abtahi AM, Stephens BF, Zuckerman SL

    Artificial Intelligence Surgerydoi:10.20517/ais.2024.40First author

  2. Brain-wide human oscillatory local field potential activity during visual working memory

    Singh B, Wang Z, Madiah LM, Gatti SE, Fulton JN, Johnson GW, Li R, Dawant BM, Englot DJ, Bick SK, Roberson SW, Constantinidis C

    iSciencedoi:10.1016/j.isci.2024.109130

  3. Network signatures define consciousness state during focal seizures

    Doss DJ, Johnson GW, Makhoul GS, Rashingkar RV, Shless JS, Bibro CE, Paulo DL, Gummadavelli A, Ball TJ, Reddy SB, Naftel RP, Haas KF, Dawant BM, Constantinidis C, Williams Roberson S, Bick SK, Morgan VL, Englot DJ

    Epilepsiadoi:10.1111/epi.18074

  4. Association Between Postsurgical Functional Connectivity and Seizure Outcome in Patients With Temporal Lobe Epilepsy

    Akbarian B, Sainburg LE, Janson A, Johnson GW, Doss DJ, Rogers BP, Englot DJ, Morgan VL

    Neurologydoi:10.1212/WNL.0000000000209816

  5. The interictal suppression hypothesis is the dominant differentiator of seizure onset zones in focal epilepsy

    Doss DJ, Shless JS, Bick SK, Makhoul GS, Negi AS, Bibro CE, Rashingkar R, Gummadavelli A, Chang C, Gallagher MJ, Naftel RP, Reddy SB, Williams-Roberson S, Morgan VL, Johnson GW, Englot DJ

    Braindoi:10.1093/brain/awae189

  6. Combined Anterior-Posterior vs. Posterior-Only Approach in Adult Spinal Deformity Surgery: Which Strategy Is Superior?

    Younus I, Chanbour H, Chen JW, Johnson GW, Metcalf T, Lyons AT, Jonzzon S, Liles C, Roth SG, Abtahi AM, Stephens BF, Zuckerman SL

    J Clin Meddoi:10.3390/jcm13030682

  7. Tractography from T1-weighted MRI: Empirically exploring the clinical viability of streamline propagation without diffusion MRI

    Cai LY, Lee HH, Johnson GW, Newlin NR, Ramadass K, Kim ME, Archer DB, Hohman TJ, Jefferson AL, Begnoche JP, Boyd BD, Taylor WD, Morgan VL, Englot DJ, Nath V, Chotai S, Barquero L, D'Archangel M, Cutting LE, Dawant BM, Rheault F, Moyer DC, Schilling KG, Gore JC, Landman BA

    Imaging Neurosci (Camb)doi:10.1162/imag_a_00259

  8. Who Can Be Discharged Home after Adult Spinal Deformity Surgery?

    Jonzzon S, Chanbour H, Johnson GW, Chen JW, Metcalf T, Lyons AT, Younus I, Liles C, Abtahi AM, Stephens BF, et al

    Journal of Clinical Medicine

  9. Indirect structural changes and reduced controllability after temporal lobe epilepsy resection

    Janson A, Sainburg L, Akbarian B, Johnson GW, Rogers BP, Chang C, Englot DJ, Morgan VL

    Epilepsiadoi:10.1111/epi.17889

2023

  1. Longer Screws Decrease the Risk of Radiographic Pseudarthrosis Following Elective Anterior Cervical Discectomy and Fusion

    Chanbour H, Bendfeldt GA, Johnson GW, Peterson K, Ahluwalia R, Younus I, Longo M, Abtahi AM, Stephens BF, Zuckerman SL

    Global Spine Jdoi:10.1177/21925682231214361

  2. Artificial Intelligence to Preoperatively Predict Proximal Junction Kyphosis Following Adult Spinal Deformity Surgery: Soft Tissue Imaging May be Necessary for Accurate Models

    Johnson GW, Chanbour H, Ali MA, Chen J, Metcalf T, Doss DJ, Younus I, Jonzzon S, Roth SG, Abtahi AM, Stephens BF, Zuckerman SL

    Spinedoi:10.1097/BRS.0000000000004816First author

  3. The interictal suppression hypothesis in focal epilepsy: network-level supporting evidence

    Johnson GW, Doss DJ, Jiang JW, Paulo DL, Cai LY, Shless JS, Negi AS, Gummadavelli A, Kang H, Reddy SB, Naftel RP, Bick SK, Williams Roberson S, Dawant BM, Wallace MT, Englot DJ

    Braindoi:10.1093/brain/awad016First author

  4. Intraoperative physiology augments atlas-based data in awake deep brain stimulation

    *Paulo DL, *Johnson GW, Doss DJ, Allen JH, González HFJ, Shults R, Li R, Ball TJ, Bick SK, Hassell TJ, D'Haese PF, Konrad PE, Dawant BM, Narasimhan S, Englot DJ

    J Neurol Neurosurg Psychiatrydoi:10.1136/jnnp-2023-331248Co-first author

  5. Deep learning segmentation of the nucleus basalis of Meynert on 3T MRI

    Doss DJ, Johnson GW, Narasimhan S, Jiang JW, Gonzalez HFJ, Paulo DL, Lucas A, Davis KA, Chang CE, Morgan VL, Constantinidis C, Dawant BM, Englot DJ

    AJNR Am J Neuroradioldoi:10.3174/ajnr.A7950

  6. Convolutional-recurrent neural networks approximate diffusion tractography from T1-weighted MRI and associated anatomical context

    Cai LY, Lee HH, Newlin NR, Kerley CI, Kanakaraj P, Yang Q, Johnson GW, Moyer D, Schilling KG, Rheault F, Landman BA

    Proceedings of Machine Learning Research

  7. Corticostriatal beta oscillation changes associated with cognitive function in Parkinson's disease

    Paulo DL, Qian H, Subramanian D, Johnson GW, Zhao Z, Hett K, Kang H, Chris Kao C, Roy N, Summers JE, Claassen DO, Dhima K, Bick SK

    Braindoi:10.1093/brain/awad206

  8. Abnormal functional connectivity of the posterior hypothalamus and other arousal regions in surgical temporal lobe epilepsy

    Jiang JW, Narasimhan S, Johnson GW, González HFJ, Doss DJ, Shless JS, Paulo DL, Terry DP, Chang C, Morgan VL, Englot DJ

    J Neurosurgdoi:10.3171/2023.1.JNS221452

  9. Structural disconnection relates to functional changes after temporal lobe epilepsy surgery

    Sainburg LE, Janson AP, Johnson GW, Jiang JW, Rogers BP, Chang C, Englot DJ, Morgan VL

    Braindoi:10.1093/brain/awad117

  10. Time-resolved correlation of distributed brain activity tracks E-I balance and accounts for diverse scale-free phenomena

    Nanda A, Johnson GW, Mu Y, Ahrens MB, Chang C, Englot DJ, Breakspear M, Rubinov M

    Cell Repdoi:10.1016/j.celrep.2023.112254

2022

  1. Localizing seizure onset zones in surgical epilepsy with neurostimulation deep learning

    Johnson GW, Cai LY, Doss DJ, Jiang JW, Negi AS, Narasimhan S, Paulo DL, González HFJ, Williams Roberson S, Bick SK, Chang CE, Morgan VL, Wallace MT, Englot DJ

    J Neurosurgdoi:10.3171/2022.8.JNS221321First author

  2. Arousal and salience network connectivity alterations in surgical temporal lobe epilepsy

    González HFJ, Narasimhan S, Goodale SE, Johnson GW, Doss DJ, Paulo DL, Morgan VL, Chang C, Englot DJ

    J Neurosurgdoi:10.3171/2022.5.JNS22837

  3. Integrating Network Neuroscience Into Epilepsy Care: Progress, Barriers, and Next Steps

    *Sinha N, *Johnson GW, Davis KA, Englot DJ

    Epilepsy Currdoi:10.1177/15357597221101271Co-first author

  4. Presurgical temporal lobe epilepsy connectome fingerprint for seizure outcome prediction

    Morgan VL, Sainburg LE, Johnson GW, Janson A, Levine KK, Rogers BP, Chang C, Englot DJ

    Brain Commundoi:10.1093/braincomms/fcac128

  5. Characterization of resting functional MRI activity alterations across epileptic foci and networks

    Sainburg LE, Little AA, Johnson GW, Janson AP, Levine KK, González HFJ, Rogers BP, Chang C, Englot DJ, Morgan VL

    Cereb Cortexdoi:10.1093/cercor/bhac035

  6. SEEG Functional Connectivity Measures to Identify Epileptogenic Zones: Stability, Medication Influence, and Recording Condition

    Paulo DL, Wills KE, Johnson GW, Gonzalez HFJ, Rolston JD, Naftel RP, Reddy SB, Morgan VL, Kang H, Williams Roberson S, Narasimhan S, Englot DJ

    Neurologydoi:10.1212/WNL.0000000000200386

  7. Temporal lobe epilepsy lateralisation and surgical outcome prediction using diffusion imaging

    Johnson GW, Cai LY, Narasimhan S, González HFJ, Wills KE, Morgan VL, Englot DJ

    J Neurol Neurosurg Psychiatrydoi:10.1136/jnnp-2021-328185First author

  8. Functional connectivity between mesial temporal and default mode structures may help lateralize surgical temporal lobe epilepsy

    Narasimhan S, González HFJ, Johnson GW, Wills KE, Paulo DL, Morgan VL, Englot DJ

    J Neurosurgdoi:10.3171/2022.1.JNS212031

  9. Network dysfunction in pre and postsurgical epilepsy: connectomics as a tool and not a destination

    Johnson GW, Doss DJ, Englot DJ

    Curr Opin Neuroldoi:10.1097/WCO.0000000000001008First author

2021

  1. MRI network progression in mesial temporal lobe epilepsy related to healthy brain architecture

    Morgan VL, Johnson GW, Cai LY, Landman BA, Schilling KG, Englot DJ, Rogers BP, Chang C

    Netw Neuroscidoi:10.1162/netn_a_00184

  2. PreQual: An automated pipeline for integrated preprocessing and quality assurance of diffusion weighted MRI images

    Cai LY, Yang Q, Hansen CB, Nath V, Ramadass K, Johnson GW, Conrad BN, Boyd BD, Begnoche JP, Beason-Held LL, Shafer AT, Resnick SM, Taylor WD, Price GR, Morgan VL, Rogers BP, Schilling KG, Landman BA

    Magn Reson Meddoi:10.1002/mrm.28678

  3. People with mesial temporal lobe epilepsy have altered thalamo-occipital brain networks

    Wills KE, González HFJ, Johnson GW, Haas KF, Morgan VL, Narasimhan S, Englot DJ

    Epilepsy Behavdoi:10.1016/j.yebeh.2020.107645

  4. Role of the Nucleus Basalis as a Key Network Node in Temporal Lobe Epilepsy

    González HFJ, Narasimhan S, Johnson GW, Wills KE, Haas KF, Konrad PE, Chang C, Morgan VL, Rubinov M, Englot DJ

    Neurologydoi:10.1212/WNL.0000000000011523

2020

  1. Seizure-onset regions demonstrate high inward directed connectivity during resting-state: An SEEG study in focal epilepsy

    Narasimhan S, Kundassery KB, Gupta K, Johnson GW, Wills KE, Goodale SE, Haas K, Rolston JD, Naftel RP, Morgan VL, Dawant BM, González HFJ, Englot DJ

    Epilepsiadoi:10.1111/epi.16686

  2. Resting-State SEEG May Help Localize Epileptogenic Brain Regions

    Goodale SE, González HFJ, Johnson GW, Gupta K, Rodriguez WJ, Shults R, Rogers BP, Rolston JD, Dawant BM, Morgan VL, Englot DJ

    Neurosurgerydoi:10.1093/neuros/nyz351

Preprints

2

2025

  1. Generalized brain-state modeling with KenazLBM

    Johnson GW, Makhoul GS, Doss DJ, Monroy Lerma BH, Cai LY, …, Worrell GA, Miller KJ, Englot DJ

    bioRxivdoi:10.1101/2025.08.10.669538First author

2024

  1. Brain-state modeling using electroencephalography: Application to adaptive closed-loop neuromodulation for epilepsy

    Johnson GW, Doss DJ, Makhoul GS, Cai LY, Bibro CE, Paulo DL, Reddy SB, Naftel RP, Haas KF, Wallace MT, Dawant BM, Crudele AN, Morgan VL, Constantinidis C, Roberson SW, Bick SK, Englot DJ

    bioRxivdoi:10.1101/2024.06.01.596884First author

Book chapters

1

2024

  1. Imaging and Stereotactic Electroencephalography Functional Networks to Guide Epilepsy Surgery

    Doss DJ, Johnson GW, Englot DJ

    Neurosurg Clin N Amdoi:10.1016/j.nec.2023.09.001